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High‑titer polyclonal antisera for dependable pneumococcal vaccine QC
Multivalent pneumococcal polysaccharide (PPV) and conjugate (PCV) vaccines include many polysaccharides with subtle structural and acetylation differences—which makes quality control complex.
High titer polyclonal antisera are designed to meet this need by recognizing multiple epitopes on each polysaccharide, enabling sensitive, reproducible identification and quantification across complex formulations.
Learn more about the superior performance of our high titer antisera in video below.
Product description
High titer pneumococcal polyclonal antisera are validated using both the Neufeld (Quellung) reaction and nephelometric analyses – methods routinely used by vaccine manufacturers and recommended by WHO for antigen control (WHO’s PCV recommendations (TRS 977, Annex 3)) [1].
| Vaccine high titer product | Standard product | |
|---|---|---|
| CoA method (CE mark) | Quellung reaction – Neufeld | Quellung reaction – Neufeld |
| Validated on other methods | Beckman Coulter IMMAGE 800 | N/A |
| Cross-reactions removed based on | Quellung reaction and Beckman Coulter IMMAGE 800 | Quellung reaction |
| Factor antisera | Cross-reactions removed for all pneumococcal serotypes included in the 13-valent and 23-valent vaccines. | Cross-reactions removed within the specific group e.g. Factor 6b only for 6B, 6C, 6D |
| Concentration | 3 times stronger than standard product | Ready to use in Quellung reaction |
Product range
All known pneumococcal serotypes are available in stock. Please contact us for further information.
References:
Recommendations to assure the quality, safety and efficacy of pneumococcal conjugate vaccines
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